Extending the Notion of Quality from Physical Metrology to

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Vallancien G, Emberton M, Harving N, van Moorselaar RJ; Alf-One Study Group. The IACUC may reconsider its decision, with documentation in Committee minutes, in light of the information provided by the principal investigator. (section 2.31 (d)(4)). (6) The IACUC may suspend an activity that it previously approved if it determines that the activity is not being conducted in accordance with the description of that activity provided by the principal investigator and approved by the Committee.... (section 2.31 (d)(6)). (e) A proposal to conduct an activity involving animals, or to make a significant change in an ongoing activity involving animals, must contain the following: (section 2.31 (e)). (1) Identification of the species and the approximate number of animals to be used; (section 2.31 (e)(1)). (2) A rational for involving animals, and for the appropriateness of the species and number of animals used; (section 2.31 (e)(2)). (3) A complete description of the proposed use of the animals; (section 2.31 (e)(3)). (4) A description of procedures designed to assure that discomfort and pain to animals will be limited to that which is unavoidable for the conduct of scientifically valuable research, including provision for the use of analgesic, anesthetic, and tranquilizing drugs where indicated and appropriate to minimize discomfort and pain to animals; and (section 2.31 (e)(4)). (5) A description of any euthanasia method to be used. (section 2.31 (e)(5)). (c) Training and instruction of personnel must include guidance in at least the following areas: (section 2.32 (c)). (1) Humane methods of animal maintenance and experimentation, including; (section 2.32 (c)(1)). (i) The basic needs of each species of animal; (section 2.32 (c)(1)(i)). (ii) Proper handling and care for the various species of animals used by the facility; (section 2.32 (c)(1)(ii)). (iii) Proper pre-procedural and post-procedural care of animals; and (section 2.32 (c)(1)(iii)). (iv) Aseptic surgical methods and procedures: (section 2.32 (c)(1)(iv)). (2) The concept, availability, and use of research or testing methods that limit the use of animals or minimize animal distress; (section 2.32 (c)(2)). (3) Proper use of anesthetics, analgesics, and tranquilizers for any species of animal used at the facility; (section 2.32 (c)(3)). (4) Methods whereby deficiencies in animal care or treatment are reported. (5) Utilization of services(e.g., National Agricultural Library, National Library of Medicine) available to provide information: (section 2.32 (c)(5)). (i) On appropriate methods of animal use; (section 2.32 (c)(5)(i)). (ii) On alternatives to the use of live animals in research; (section 2.32 (c)(5)(ii)). (iii) That could prevent unintended and unnecessary duplication of research involving animals; and (section 2.32 (c)(5)(iii)). (iv) Regarding the intent and requirements of the Act. (section 2.32 (c)(5)(iv)).

Pages: 34

Publisher: CreateSpace Independent Publishing Platform (July 30, 2008)

ISBN: 1495925390

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